But at 15:43 of the third, Red Wings defenseman Marc Staal was called for a controversial tripping penalty and the Predators took advantage.
Just 19 seconds into the power play, former Red Wings draft pick Calle Jarnkrok threw a shot on net, and after Greiss made the initial pad save, Mikael Granlund grabbed the rebound right on the doorstep and put the puck in the back of the net to tie the game once again, at 2-2, with 4:58 remaining in regulation.
The three-on-three overtime session ping-ponged back and forth with both teams creating several chances, but both goalies stood tall, sending the game into a shootout.
Larkin and Zadina both missed their opportunities in the shootout for the Red Wings and Nashville converted both of its attempts to earn the win.
Despite the loss, which made him 1-1-2 in his last four appearances in net, Greiss has played great for the Wings lately, earning a 1.86 goals-against average and a .940 save percentage in that stretch.
Red Wings coach Jeff Blashill said Greiss has often been the best player on the ice for Detroit this season and has shown a lot of grit despite not earning the results he'd like throughout the year.
"He's been through lots in his pro career. He knows how to handle it," Blashill said about the 12-year NHL veteran. "That's part of the advantage of having a guy like that, who's been through it. Obviously, everybody's confidence can get shaken at times, but he's been able to stay with it and just work, and I think he's put himself in a better spot in terms of where his goaltending's at."