The Wings have now lost 14 straight regular-season games to the Lightning and 13 straight regular-season games in Tampa.
Thomas Vanek (power play) and Anthony Mantha scored for the Wings. Ryan McDonagh and Nikita Kucherov (two) lit the lamp for the Lightning.
Detroit goaltender Jonathan Bernier made 30 saves. Tampa Bay goalie Louis Domingue had 22 saves.
The Wings fell to 24-34-10 while the Lightning improved their league-best record to 52-13-4.
Up next for the Wings is the second half of their back-to-back set Sunday evening in south Florida against the Panthers.
The Lightning travel to Toronto to face the Maple Leafs Monday and then will meet the Wings in Detroit Thursday.
1. The streak: There are a lot of players currently playing for the Wings who have not been a part of the long losing streak to the Lightning. But the fact remains that they have now lost 14 in a row in the regular season, dating back to a 2-1 win on Nov. 3, 2015. If you include the playoffs, the streak is also 14, which goes back to April 17, 2016, a 2-0 Game 3 victory in Detroit. The Wings have lost 13 in a row in the regular season in Tampa, with their last victory coming Feb. 17, 2011, a 6-2 win. If you include the playoffs, the Wings have lost 13 straight in Tampa, which goes back to Game 5 in 2015. The Wings will have one more chance to snap the skid next Thursday at Little Caesars Arena.
Quotable: "It's obviously frustrating. They've had our number here. Obviously, a lot of one-goal games. We got a chance next week to play these guys, so look forward to that opportunity but I didn't think we were quick enough executing out of our own zone and playing in our own zone for a lot of the game and it's tough to get anything going in the offensive zone because a lot of times you're changing." -- Justin Abdelkader
Quotable II: "It's really frustrating. I think it started that year they won in the playoffs. So it's pretty much the whole time I've been here. It sucks every time we're in against these guys. I don't know what it is. Bernie played unbelievable. We couldn't get anything offensively, couldn't grind in their zone like we wanted to." -- Mantha