When Dylan Larkin, Anthony Mantha and Tyler Bertuzzi were put together as a line last season, they caught fire toward the end of the year.
So much so that Red Wings coach Jeff Blashill put them back together to start training camp.
The chemistry continued in the first game of the season.
Bertuzzi (two, one empty net), Mantha and Larkin each scored for the Wings.
But it was new alternate captain Luke Glendening who broke a 3-3 tie at 9:24 of the third to help lift the Wings to a 5-3 victory.
The Red Wings have won 10 of the last 11 meetings with the Predators, including a six-game winning streak in Nashville dating back to 2014-15.
Viktor Arvidsson (power play), Filip Forsberg and Mattias Ekholm scored for the Predators.
Detroit goaltender Jimmy Howard made 39 saves, many of them spectacular ones, especially as the Wings settled into their first game of the season.
Nashville netminder Juuse Saros had 23 saves.
Up next for the Wings is their home opener Sunday night against the Dallas Stars. The Predators host the San Jose Sharks Tuesday night.
1. Tyler Bertuzzi/Luke Glendening: On a perfect tic-tac-toe play, Mantha dropped the puck to Larkin, who fed Bertuzzi in the right circle for a one-timer that beat Saros at 11:40 of the first period. Bertuzzi, who provides a lot of grit for the top line, then assisted on Mantha's goal just 1:11 after his own goal. He also got the second assist on Larkin's goal. With the Red Wings fighting to maintain their lead, Bertuzzi made a heads-up play to get the empty-net goal on a wraparound at 18:58 of the third. According to NHL Public Relations, Bertuzzi's four points tied the Wings' record for most points in a season opener. Mike Green had four assists on Oct. 5, 2017 against the Minnesota Wild. Bertuzzi finished with 26 shifts for 19:48, had two shots, one giveaway and was plus-4. Glendening, elevated to the second line with Valtteri Filppula and Taro Hirose with Andreas Athanasiou unable to go, is generally not considered a goal scorer. But he certainly looked like one at 9:24 of the third, lifting the puck over Saros into the top of the net. Filppula got the lone assist. Glendening also assisted on Bertuzzi's empty-netter. Glendening has three goals and three assists in 11 games against Nashville. Glendening finished with 25 shifts for 14:21, had two shots, two hits, one blocked shot, was 8-for-16 in face-offs and was plus-1.