With 20 games to play this season, Detroit currently trails the Pittsburgh Penguins by six points for the second and final wild card spot in the Eastern Conference.
"I think this is probably crazy to say, but we're still hanging around," said captain Dylan Larkin, who scored the Red Wings' lone goal against the Isles. "We're still right there. We have to win hockey games."
According to goalie Magnus Hellberg, the key for Detroit will be to move on from the raw emotions of the trade deadline and focus on the final stretch.
"(Those) guys were great assets for the team, but that's the way it goes in this business," Hellberg said. "This is the team that is going to do it. We have to bear down and try to figure out how to win these types of games, for sure."