| Opponent | Date | Time (ET) | Location | |
|---|---|---|---|---|
| Minnesota Wild | 10/5/17 | 7:30 p.m. | Little Caesars Arena | |
| Ottawa Senators | 10/7/17 | 7:00 p.m. | Canadian Tire Centre | |
| Dallas Stars | 10/10/17 | 8:30 p.m. | American Airlines Center | |
| Arizona Coyotes | 10/12/17 | 10:00 p.m. | Gila River Arena | |
| Vegas Golden Knights | 10/13/17 | 10:30 p.m. | T-Mobile Arena | |
| Tampa Bay Lightning | 10/16/17 | 7:30 p.m. | Little Caesars Arena | |
| Toronto Maple Leafs | 10/18/17 | 7:30 p.m. | Air Canada Centre | |
| Washington Capitals | 10/20/17 | 7:30 p.m. | Little Caesars Arena | |
| Vancouver Canucks | 10/22/17 | 7:00 p.m. | Little Caesars Arena | |
| Buffalo Sabres | 10/24/17 | 7:30 p.m. | KeyBank Center | |
| Tampa Bay Lightning | 10/26/17 | 7:30 p.m. | Amalie Arena | |
| Florida Panthers | 10/28/17 | 7:00 p.m. | BB&T Center | |
| Arizona Coyotes | 10/31/17 | 7:30 p.m. | Little Caesars Arena |
