Columbus, third in the Metropolitan Division, is 7-0-1 in its past eight games and has 39 points since Dec. 9 (17-2-5), the most in the NHL in that span.
The Blue Jackets, who start a four-game homestand, are 8-1-1 in the past 10 home games, outscoring opponents 34-13.
Aleksander Barkov could miss his second straight game for the Panthers because of a lower-body injury the forward sustained in a 4-0 loss to the Montreal Canadiens on Saturday.
Florida is 7-1-0 in the past eight games after defeating the Toronto Maple Leafs 5-3 on Monday.