Hornqvist will be a game-time decision after practicing Wednesday and participating in the morning skate Thursday. He had sat out against the Colorado Avalanche on Monday because of an upper-body injury.
Pittsburgh is 2-5-0 in its past seven games since winning four in row from Nov. 25-Dec. 2.
The Blue Jackets look for their second win in as many days; they won 4-2 against the Toronto Maple Leafs on Wednesday. They had lost their previous two games, against the Carolina Hurricanes on Saturday and the Boston Bruins on Monday by a combined score of 9-3.
Columbus (43 points) is tied with the New Jersey Devils for second place in the Metropolitan Division, two points behind the first-place Washington Capitals. Pittsburgh (37 points) is seventh.