The Maple Leafs are 9-1-0 in their past 10 games and have scored four goals or more in in seven of their past nine.
Toronto is in third place in the Atlantic Division, six points behind the first-place Tampa Bay Lightning and three behind the Boston Bruins.
The Penguins will attempt to win their 11th consecutive home game; their 10-game streak is their longest since they won a Pittsburgh-record 13 straight at home from Nov. 15, 2013, to Jan. 15, 2014.
Pittsburgh, 8-1-1 in its past 10 games, is three points behind the Metropolitan Division-leading Washington Capitals.
The Maple Leafs won 4-3 against the Penguins at PPG Paints Arena on Dec. 9.