Getzlaf left practice early Friday because of a virus going around the team, the Orange County Register reported. His status for the game is uncertain.
Anaheim has been outscored 7-2 through the first two games of the trip, losing on back-to-back days against the Philadelphia Flyers (4-1) and New Jersey Devils (3-1) on Tuesday and Wednesday.
New York returns home after a 3-2 shootout win at the Boston Bruins on Thursday. The Islanders are 3-0-1 in their past four home games against the Ducks.
The Ducks ended the Islanders' 17-game point streak with a 3-0 victory at Honda Center on Nov. 25.