Selected by the Edmonton Oilers in the first round (No. 22) of the 2008 NHL Draft, Eberle scored shorthanded in his NHL debut against the Calgary Flames on Oct. 7, 2010. He led the Oilers during his rookie season with 43 points (18 goals, 25 assists) in 69 games and was named to the 2011 NHL All-Star Game.
Eberle broke out in his second NHL season (2011-12); he was named to the NHL All-Star Game and had NHL career highs with 34 goals and 76 points in 78 games. He had 10 minutes in penalties and finished second to Brian Campbell of the Florida Panthers in voting for the Lady Byng Trophy, awarded to the player judged to best combine sportsmanship and gentlemanly play and a high standard of play.