The Blues are 8-1-0 in their past nine after a five-game winless streak (0-3-2) and first in the Central Division and Western Conference, two points ahead of the Colorado Avalanche.
St. Louis can sweep the season series against Chicago for the first time. The Blues won 4-0 at United Center on Dec. 2 and 4-3 and 6-5 at Enterprise Center on Dec. 14 and Feb. 25, respectively.
The Blackhawks, 4-1-0 in their past five after going 1-4-0 in their previous five, trail the Vancouver Canucks, Nashville Predators and Winnipeg Jets by six points for the first wild card into the Stanley Cup Playoffs from the Western Conference.