Talbot stopped all 24 shots he faced in 40 minutes of work Thursday, but the Flames dropped a 4-1 decision to the San Jose Sharks.
Artyom Zagidulin tagged in for the final 20 in what was then a 0-0 game, turning aside six of the 12 pucks he was tested with.
Evander Kane scored the icebreaker at 3:17 of the third period as he redirected a Brent Burns blast in front, leaving Zagidulin with no chance on the play.
The goal came on San Jose's 29th shot, and the fifth the Flames' highly touted goalie prospect faced.
Burns put the game away with 9:01 on the clock, stepping up at the right point and fooling Zagidulin with a shot from the wall, beating the netminder up high, over the left shoulder.
Dylan Gambrell added a pair less than a minute apart late in the third - first getting a stick on a shot in the high slot to make it 3-0 at 13:27, and then floating one through traffic to make it a four-goal game at 13:51.
Burns finished the night with four helpers to lead the way offensively.
Justin Kirkland broke the shutout with 4:02 to play off a feed from Buddy Robinson, but it was too little, too late.
The Flames - who dressed only six regulars and recalled eight players from Stockton to round out the roster on a long, there-and-back travel day - faced a veteran Sharks team loaded with primetime talent.
Joe Thornton, Erik Karlsson, Burns, Kane and many more all dressed in front of their home fans.
Talbot was under siege early as he faced a barrage of quality chances, thanks in large part to a pair of Oliver Kylington penalties that put the visitors down a man twice, less than five minutes apart.
However, the 'Goalbuster' stood tall, stonewalling Danil Yurtaykin's backdoor tap-in attempt, before scrambling back into position and kicking out the left pad to deny Karlsson's blast from the opposite circle.
