The Predators, who clinched a berth in the Stanley Cup Playoffs on Monday, are in second place in the Central, two points behind the Winnipeg Jets, two ahead of the St. Louis Blues and four ahead of the Dallas Stars. Nashville is 4-1-1 in its past six games after going 2-4-0 in their previous six.
The Penguins can tie the New York Islanders for second place in the Metropolitan Division with a win. Pittsburgh, which has won three straight and is 10-2-3 in its past 15 games, is two points behind New York and five behind the Washington Capitals.
Pittsburgh defeated Nashville 2-1 in a shootout at Bridgestone Arena on March 21.