Vegas, which has won seven of its first eight games, can become the third team with a five-game winning streak during its inaugural season, joining the 1926-27 New York Rangers and 1979-80 Edmonton Oilers.
Golden Knights forward Erik Haula was activated from injured reserve. He had missed the previous four games because of a lower-body injury.
After a 4-1-0 start, the Avalanche are 1-3-0 in their past four games. They ended a three-game losing streak with a 5-3 victory against the Dallas Stars on Tuesday. Defenseman Patrik Nemeth (lower body) is expected to return to the lineup after not playing against the Stars.