Reilly sustained an upper-body injury in the second period of a 3-2 overtime loss to the Philadelphia Flyers on Thursday. It was the fourth straight loss for the Maple Leafs (0-1-3), their longest losing streak of the season.
Craig Anderson will start his seventh consecutive game for the Senators. He is 3-2-1 with 20 goals against in his previous six starts.
Ottawa, 4-3-1 in its past eight games, allowed three second-period goals in a 4-1 loss to the St. Louis Blues on Thursday and has been outscored 65-36 in the second period this season. The minus-29 goal differential is the worst in the League.