Pittsburgh, which begins a three-game road trip, has outscored the opposition 12-4 in its past four games. The Penguins are 6-1-0 in their past seven games.
Defenseman Alex Pietrangelo will return to the Blues lineup. He missed the past 11 games with a broken right hand sustained Nov. 30 against the Colorado Avalanche. The Blues, who have won five of their past seven, went 6-4-1 without Pietrangelo.
This will be the 4,000th regular-season game for the Blues, who joined the NHL in 1967-68, becoming the 10th team in League history to reach that milestone.