The forward has missed 16 games with a lower-body injury sustained against the St. Louis Blues on Oct. 21. Colorado has gone 8-7-1 without Rantanen, who has 12 points (five goals, seven assists) in nine games.
Blackhawks forward Patrick Kane will try to extend his point streak to 15 games. He had a goal in a 5-2 loss to Colorado at United Center on Friday and has 23 points (10 goals, 13 assists) in a 14-game streak, the longest in the NHL this season.
Robin Lehner is expected to start for the Blackhawks, who are 1-3-1 in their past five games after going 5-0-1 in their previous six.
Philipp Grubauer is expected to start for the Avalanche, who have won two straight games and are 7-3-0 in their past 10.