McDonagh, the Rangers' captain, missed the past four games because of an abdominal strain and hasn't played since Nov. 19.
New York will be without center Mika Zibanejad (concussion) for the second straight game.
The Hurricanes are playing the first of 10 road games this month, including nine of their next 11. They will try to extend their point streak to three games (1-0-1). Carolina lost to New York, 6-1 at PNC Arena on Nov. 22.