Fleury allowed five goals on 33 shots in a 5-4 loss to the Penguins in his return on Feb. 6, 2018. He played for Pittsburgh from 2003-17, winning the Stanley Cup in 2009, 2016 and 2017.
Goalie Malcolm Subban, who is out with a lower-body injury, started in a 4-2 loss to the Penguins when the Golden Knights last played in Pittsburgh on Oct. 11, 2018.
Fleury needs one victory to tie Terry Sawchuk (445) for seventh on the NHL all-time wins list. Vegas has won three of its past four games (3-1-0), including a 3-2 shootout victory against the Ottawa Senators on Thursday.
Pittsburgh has outscored its opponents 23-11 during a five-game winning streak. It will play the second half of a home back-to-back after defeating the Dallas Stars 4-2 on Friday.