Mrazek is 2-2-1 with a 2.55 goals-against average and .924 save percentage in five games this season, including a 36-save shutout in a 4-0 win at the Edmonton Oilers on Sunday.
The Red Wings have won four of their past five games following a six-game losing streak (0-5-1).
Defenseman Rasmus Andersson will make his season debut for the Flames, who are 3-1-0 in their past four games. Andersson, 21, has played one NHL game in his career, a 3-1 loss at the San Jose Sharks on April 8 last season. He has eight points (one goal, seven assists) in 10 games with Stockton of the American Hockey League this season.