Mikael Backlund returned to the lineup after missing Tuesday's 4-3 overtime win against the Canucks with a lower-body injury.
That led to a rejig of personnel for the tilt (see The Lineup below), which included Brett Ritchie drawing in to play his first game as a Flame.
Ritchie ended up playing with Johnny Gaudreau and Sean Monahan for a good portion of the evening.
On his first shift of the game, he made his presence known by laying a big hit on Olli Juolevi behind the Vancouver net.
The Canucks opened the scoring just 1:46 in after a Calgary turnover, Bo Horvat feeding Jordie Benn on a 2-on-1, the defenceman snapping a shot that went above the pad and under the glove of Jacob Markstrom.
The Flames had some good cracks to knot it up in the first.
The aforementioned Ritchie burst in on a partial brekaway but Braden Holtby got a piece of the shot with his glove.
Then it was Milan Lucic who stepped into big Canucks defenceman Tyler Myers behind the net, getting the puck and driving out but unable to jam the puck home.
There was a wild sequence early in the second period, as Tanner Pearson was chasing a loose puck for a breakaway and Markstrom came out to try and play it, the two meeting head-on halfway to the Flames blueline, the Canucks forward flipping in the air over top the Calgary 'tender before landing hard on the ice.
The Canucks made it 2-0 later on a similar play, Markstrom not able to win a footrace to a puck and Horvat grabbing it and skating around him to throw it into an open net at 7:37.
Johnny Gaudreau - the current Flames leader in goals with nine season and the OT hero Monday - got the puck at the side of the Canucks net but his backhand attempt from a great spot looked to be tipped over the Vancouver net.
At the other end, Elias Pettersson snapped a puck off the post looking to add to the lead.
Andrew Mangiapane got the Flames on the board 18:13, Mark Giordano's long stretch pass to him tipped by Benn, but the Fames forward able to scoop it up and cut hard across the net and wrap it around the right pad of a laid out Holtby.