The event consists of club brass meeting with any number the top skaters and goaltenders from North America and Europe, before the gruelling fitness testing takes place at the home of the Sabres on Friday and Saturday of this week.
Seventy-seven of the top North-American prospects and 27 of the top international competitors, totalling 56 forwards, 38 defencemen and 10 goaltenders, comprise this year's invite list.
By now, members of the Flames - led by Head Amateur Scout Tod Button - have already met most of the prospects in a one-on-one setting as part of their viewings throughout the hockey season.
But the Combine is unique. It offers a chance for teams to loop back on players of interest, dig deeper into their season as a whole, and allow the prospects to get the know the organization a little better, too.
"It's a great opportunity for us to really focus on the players we have the most interest in leading up to the draft," Button said. "It's an information-gathering session, more than anything.
"A lot of people, including the prospects themselves, think of it as kind of a job interview, but we try to create a friendly, relaxed environment that the players can feel comfortable in. I, personally, don't see much value in trying to trip them up with strange questions and things like that.
"We've talked a lot of hockey already. It's best that we use this time to get to know them better as people - their hobbies, interests, family, and of course, what drives them."