Matthew Tkachuk assisted on all three of Brady’s goals.
Brady Tkachuk, who also had an assist, scored his fourth career hat trick to give the Panthers a 3-1 lead in a span of 8:03.
He was acquired from the Ottawa Senators on June 23, and recorded his first point with Florida with an assist in a 5-3 loss at the Buffalo Sabres on Monday.
Sam Reinhart scored twice and had an assist, Carter Verhaeghe scored twice, and Seth Jones had four assists for the Panthers (3-2-2), who had lost four of five (1-2-2). Akira Schmid made 24 saves.
Kent Johnson scored, and Damon Severson had two assists for the Blue Jackets (2-3-0), who have lost three of four (1-3-0). Cam Talbot allowed six goals on 23 shots before being replaced at 16:36 of the third period by Jet Greaves, who made four saves.
Johnson gave Columbus a 1-0 lead at 14:11 of the first period.
Brady Tkachuk tied it 1-1 at 2:27 of the second period with a shot from the high slot, and put Florida ahead 2-1 at 6:00 on the power play.
He then completed the natural hat trick with a power-play goal at 10:30.
Verhaeghe extended it to 4-1 at 17:50 on the power play during a 5-minute major by Mathieu Olivier for slashing Uvis Balinskis.
Matthew Tkachuk has 10 points (three goals, seven assists) during a six-game point streak. He tied his NHL career highs of five points and five assists.
Reinhart pushed it to 5-1 at 1:20 of the third with a power-play goal by tipping a Matthew Tkachuk shot.
Verhaeghe scored at 3:28 of the third to make 6-1.
Denton Mateychuk cut it to 6-2 at 13:47 and Cole Sillinger made it 6-3 at 14:09.
Reinhart scored into an empty net at 17:43 for the 7-3 final.