The Predators will also clinch the Central Division if they get a point against the Blackhawks and both the Winnipeg Jets and St. Louis Blues lose in any fashion, or if both the Jets and Blues lose in regulation.
Nashville, which is one point ahead of Winnipeg and St. Louis, has won two consecutive games and is 7-2-1 in its past 10 games.
The Blackhawks have won back-to-back games and are 3-0-2 in their past five. They defeated the Dallas Stars 6-1 on Friday. Forward Patrick Kane has seven points (three goals, four assists) in his past five games and needs two goals to tie his NHL career high of 46 set in the 2015-16 season.