The Flames, who've fallen into second place in the Pacific Division, one point behind the San Jose Sharks, are 0-2-1 since a 4-3 road victory against the Carolina Hurricanes on Feb. 3.
The Panthers, who have lost back-to-back games after going 6-2-0 in their previous eight, are 13 points behind the Pittsburgh Penguins for the second wild card into the Stanley Cup Playoffs from the Eastern Conference.
Goalie James Reimer will start for the Panthers. He was pulled after allowing three goals on 12 shots in his last start, a 5-2 loss to the Tampa Bay Lightning on Sunday.