Defenseman Sean Durzi led the way on offense for Guelph, scoring both of his team's goals.
George Burnett's troops now have a 1-0-1 record in two games at the Memorial Cup.
For their part, the Mooseheads are now assured of a spot in the semifinal thanks to the win. The hosts won their first game of the tournament against the WHL champions, the Prince Albert Raiders.
The final game of the preliminary round for Guelph and Suzuki takes place on Tuesday against the Raiders.