After a goalless second, that saw Mrazek get hurt in the final seconds of the period, Toronto attempted to mount a comeback in the third that saw them get on the board at 3:11 thanks to a Spezza power play goal.
The Maple Leafs reduced the deficit to a goal at 8:50 on another power play marker as Nylander scored his second goal of the season and despite firing 25 attempts on goal in the third, Toronto was unable to break through Forsberg again. His 46 saves were a new career high and tied for the third most saves by a Sens goaltender at home in franchise history.
"Forsberg was exceptional tonight," Tim Stützle said. "He made so many unreal stops and kept us in the game."
Drake Batherson played his 100th NHL game tonight while Mete appeared in his 200th NHL contest.
"I really got goosebumps from the fans," Stützle said. "I think with their support, it was the biggest reason we won the game tonight."
The Sens are back in action again Saturday when they visit Toronto at 7pm.