Despite losing 6-5 in overtime to the Boston Bruins on Monday, the Sharks are 7-1-1 in their past nine games and 14-4-1 in their past 19. They have allowed two goals in six of their past eight games.
San Jose is second in the Pacific Division and the Western Conference, three points behind the Calgary Flames, entering the opener of a four-game road trip.
The Penguins, who have scored at least four goals in five of six games, are 4-1-0 since an 0-3-1 slide. They are third in the Metropolitan Division, five points behind the first-place New York Islanders and two points behind the Washington Capitals for second place.
It's the last game for Pittsburgh before the 2019 Coors Light NHL Stadium Series against the Philadelphia Flyers at Lincoln Financial Field on Saturday (8 p.m. ET; NBC, SN360, SN1, TVAS2).