Pavel Zacha, Mason Lohrei, Marat Khusnutdinov and Casey Mittelstadt scored, and JJ Peterka had two assists for the Bruins (4-2-0), who finished a three-game homestand 2-1-0. Jeremy Swayman made 14 saves.
Porter Martone scored, and Dan Vladar made 27 saves for the Flyers, who have yet to win this season (0-4-2).
Zacha's first goal of the season gave the Bruins a 1-0 lead at 12:21 of the first period. Pastrnak fed Zacha with a backhand pass in the high slot and his wrister knuckled toward Vladar, who got his left pad on it, but the puck trickled over the line.
Lohrei increased Boston's lead to 2-0 at 17:11 of the second period. After Swayman made a blocker save, it helped the Bruins produce a 4-on-2 in transition, allowing Lohrei to jump into the play. Peterka fed Lohrei, who beat Vladar from the left circle.
Khusnutdinov's point-blank goal pushed it to 3-0 at 1:55 of the third period, driving home Minten's pass from behind the net.
Martone cut the deficit to 3-1 with a power-play goal at 6:32.
Mittelstadt made it 4-1 at 9:21, redirecting an Elias Lindholm centering pass through the five-hole.
Minten made it 5-1 at 15:59 with his second goal of the season. The 22-year-old signed a seven-year, $50.4 million contract ($7.2 million average annual value) with the Bruins on Sept. 8, which begins next season.
Flyers forwards Travis Konecny (lower body) and Cam York (upper body) did not play and are each day to day. Prior to the game, the Flyers announced that defenseman Rasmus Ristolainen was placed on injured reserve retroactive to Oct. 3 with an upper-body injury and forward Nikita Grebenkin had back surgery and will be out at least four months.
