With 3:25 left in the period, Nyquist left the game with a lower-body injury, sustained in a knee-on-knee collision with Oilers defenseman Eric Gryba. Blashill said Nyquist was day to day.
Frk gave the Red Wings a 3-0 lead at 11:13 of the second period, converting a pass from Mantha on a 2-on-1 rush. Mantha faked a shot and slid the puck past Oilers defenseman Adam Larsson to Frk.
"I think things got away from us a little bit," Oilers center Ryan Nugent-Hopkins said. "Definitely not the way we wanted to play after that first goal. For whatever reason, we just kind of stopped defending a little bit and kind of went for it. It wasn't our best night for sure. We just have to regroup now."
Mantha scored on the power play at 6:30 of the third period to make it 4-0. He got to a rebound in front off a shot by Frk from the point.
"I think [this was] one of the better games since I've been here," said Nielsen, who signed with Detroit on July 1, 2016, after 10 seasons with the New York Islanders. "It was 60 minutes, it was very few mistakes, we got pucks deep, [we] were good on the forecheck. It was a very solid, simple road game. Hopefully, we've learned something from it."