"It's a good start for me. I didn't play for a long time," said Varlamov, who is 2-0-0 after being sidelined for the final 40 games last season and having two hip surgeries, one in January and one in February. "Came back and started the season with two wins. It brings confidence to the team. I thought today we played a very solid game."
Tuukka Rask made 19 saves for the Bruins (1-1-0), who played without center Patrice Bergeron for the second straight game because of a lower-body injury. Andrighetto got the Avalanche on the board at 4:41 of the first period with a wrist shot from the high slot off a pass by Mikko Rantanen.
Compher scored shorthanded at 13:22 for a 2-0 lead. The Bruins outshot the Avalanche 11-5 in the first period but had nothing to show for their efforts.
"We had plenty of time to get back in the game," coach Bruce Cassidy said. "The core group that we rely on just wasn't a good effort, young, old, in between. And clearly put myself in that category. We're supposed to be ready to play at home, especially after a couple days off. So that was the biggest disappointment for me."
Yakupov scored his first goal to give Colorado a 3-0 lead at 6:07 of the third after he won a race to Matt Duchene's clearing pass in Boston's end and fired the puck into the net Rask vacated while attempting to play the puck. Yakupov closed the scoring with an empty-net goal at 19:16.