Blackhawks coach Derek King said he was pleased to see de Haan and Murphy score.
"It's huge for where we are," King said. "Maybe some guys are not scoring right away, [but] you get contributions from other players and that's what we need."
Boone Jenner finished a backhand feed from Nyquist to give the Blue Jackets a 1-0 lead at 12:51 of the first period.
DeBrincat tied it 24 seconds later at the edge of the right face-off circle off a pass from Riley Stillman to make it 1-1 at 13:15.
"Myself and the other leaders, we have to lead by example and bring everyone into it," Jenner said. "We have to up our level. It starts with us and goes through the lineup. It starts tonight, the battles and the energy and getting into the game a little bit more."
Chicago played without defensemen Seth Jones and Jake McCabe; each entered NHL COVID-19 protocol before the game. Jakub Galvas made his NHL debut and was plus-1 in 23:40 of ice time, including 6:53 on the power play and 1:51 on the penalty kill.
"I honestly can't sit here and lie about it, I was very surprised how good he was," King said.
It would have been Jones' first game against the Blue Jackets since being traded to the Blackhawks on July 23 for defenseman Adam Boqvist, a first-round pick and a second-round pick in the 2021 NHL Draft, and a first-round pick in the 2022 NHL Draft or 2023 NHL Draft. Jones played the previous six seasons for Columbus, scoring 223 points (50 goals, 173 assists) in 381 regular-season games. He helped the Blue Jackets qualify for the Stanley Cup Playoffs in four seasons and scored 20 points (five goals, 15 assists) in 31 postseason games.
NOTES: Chicago has won seven straight at Columbus. … Kane has scored 72 points (23 goals, 49 assists) in 55 games against the Blue Jackets. … Stillman has one goal and two assists during a three-game point streak. … Boqvist played his 100th NHL game; his first 76 were for the Blackhawks. … Blue Jackets goalie Elvis Merzlikins was in uniform and served as the backup for the first time since he sustained a lower-body injury against the Carolina Hurricanes on Jan. 1.