The Wild's opponent on Thursday has managed to weather injuries to a number of critical players on its roster, including captain Gabriel Landeskog and forward Mikko Rantanen, both of which have been out multiple weeks with injuries.
Forwards Colin Wilson,Tyson Jost and Matt Calvert also missed Colorado's 3-2 win Tuesday in Calgary, with only Jost expected to make the trip to Minnesota.
Despite all those injuries, the Avalanche have a 3-1 record in the first four games of a five-game, 10-day road trip that concludes in St. Paul, a trip that began in Winnipeg on Nov. 12 and spanned western Canada.
Colorado has won five of its past six overall since starting the month of November with three consecutive losses.
The game Thursday marks the second of five meetings between the Central Division rivals this season and the first at Xcel Energy Center.
Landeskog's goal late in the second period on Oct. 6 was the game-winning marker in a 4-2 Avalanche victory at Pepsi Center in the second game of the regular season for both clubs.
Nathan MacKinnon leads Colorado with 13 goals and 31 points while rookie defenseman Cale Makar has been outstanding as well, posting five goals and 23 points in 21 games to go with a plus-9.
In the absence of Landeskog and Rantanen, former Washington Capital Andre Burakovsky has stepped up. He has 10 goals and 18 points while fellow newcomer, Joonas Donskoi, has nine goals and 15 points.
Goaltender Philipp Grubauer returned from injury in Calgary to earn the victory. He is 7-3-2 in 12 starts this season with a 2.73 goals-against average and a .917 save percentage.