| PLAYER | INJURY | DATE OF INJURY | GAMES MISSED | RETURN |
| Zach Parise | Illness | 4/4/19 | 2 | -- |
| Zach Parise | Lower body | 3/24/19 | 4 | 4/4/19 |
| Joel Eriksson Ek | Lower body | 3/14/19 | 7 | 3/31/19 |
| Mikko Koivu | ACL and meniscus tear | 2/9/19 | 29 | -- |
| Matt Dumba | Ruptured right pectoralis muscle | 12/18/18 | 50 | -- |
| Luke Kunin | Lower body | 3/8/19 | 2 | 3/14/19 |
| Victor Rask | Lower body | 2/17/19 | 12 | 3/11/19 |
| Pontus Aberg | Lower body | 2/5/19 | 6 | 2/21/19 |
| Eric Fehr | Lower-body | 1/31/19 | 9 | 2/2/19 |
| JT Brown | Illness | 1/23/19 | 1 | 2/1/19 |
| Nick Seeler | Upper body | 12/29/18 | 2 | 01/03/19 |
| Jason Zucker | Illness | 12/15/18 | 1 | 12/18/18 |
| Mikko Koivu | Lower body | 12/7/18 | 4 | 12/18/18 |
| Greg Pateryn | Illness | 11/27/18 | 1 | 12/18/18 |
| Devan Dubnyk | Illness | 11/23/18 | 1 | 11/27/18 |
| Zach Parise | Illness | 11/15/18 | 1 | 11/17/18 |
| Matt Hendricks | Lower Body | 11/6/18 | 3 | 11/12/18 |
| Eric Staal | Illness | 11/6/18 | 2 | 11/8/18 |
| Matt Hendricks | Lower Body | 10/16/18 | 7 | 11/6/18 |
| Joel Eriksson Ek | Lower body | 10/11/18 | 6 | 10/27/18 |
| Luke Kunin | Left ACL tear | 3/4/18 | 2 | 10/07/18 |
| Total Man Games Lost | 161 |