| PLAYER | INJURY | DATE OF INJURY | GAMES MISSED | RETURN |
| Zach Parise | Sternum fracture | 4/15/18 | 3 | -- |
| Ryan Suter | Right ankle fracture | 3/31/18 | 10 | -- |
| Gustav Olofsson | Upper body | 3/29/18 | 5 | 4/11/18 |
| Jared Spurgeon | Partial right hamstring tear | 3/13/18 | 12 | 4/11/18 |
| Nick Seeler | Right biceps strain | 3/4/18 | 3 | 3/13/18 |
| Luke Kunin | Left ACL tear | 3/4/18 | 22 | -- |
| Jonas Brodin | Left hand | 2/6/18 | 9 | 2/27/18 |
| Nino Niederreiter | Lower body | 1/9/18 | 8 | 2/2/18 |
| Nino Niederreiter | Lower body | 12/22/17 | 5 | 1/4/18 |
| Devan Dubnyk | Lower body | 12/12/17 | 6 | 12/27/17 |
| Jared Spurgeon | Groin strain | -- | 9 | 12/17/17 |
| Landon Ferraro | Hip | 10/20/17 | 7 | 11/4/17 |
| Nino Niederreiter | High left ankle sprain | 10/12/17 | 6 | 10/31/17 |
| Charlie Coyle | Right fibula fracture | 10/12/17 | 16 | 11/20/17 |
| Marcus Foligno | Left facial fracture | 10/12/17 | 1 | 10/20/17 |
| Mikael Granlund | Groin | -- | 5 | 10/24/17 |
| Zach Parise | Microdiscectomy surgery | -- | 39 | 1/2/18 |
| Total Man Games Lost | 166 |