| PLAYER | INJURY | DATE OF INJURY | GAMES MISSED | RETURN |
| Marcus Foligno | Illness | 1/21 | 1 | 1/24 |
| Filip Gustavsson | Illness | 1/4 | 1 | 1/8 |
| Mats Zuccarello | Upper Body | 1/4 | 2 | 1/10 |
| Jake Middleton | Illness | 12/27 | 1 | 12/29 |
| Marcus Foligno | Lower Body | 12/21 | 3 | 12/31 |
| Jonas Brodin | Lower Body | 11/28 | 4 | 12/9 |
| Filip Gustavsson | Upper Body | 11/26 | 1 | Backed up 12/1 |
| Brandon Duhaime | Upper Body | 11/23 | 18 | 1/7 |
| Jonas Brodin | Illness | 11/23 | 2 | 11/27 |
| Marc-Andre Fleury | Upper Body | 11/15 | 3 | 11/25 |
| Jordan Greenway | Upper Body | 11/8 | 6 | 11/23 |
| Brandon Duhaime | Upper Body | 11/1 | 5 | 11/15 |
| Ryan Hartman | Upper Body | 10/30 | 21 | 12/18 |
| Marcus Foligno | Upper Body | 10/29 | 6 | 11/11 |
| Jordan Greenway | Upper Body | 10/20 | 7 | 11/8 |
| Jon Merrill | Upper Body | Offseason Surgery | 4 | 10/22 |
| Jordan Greenway | Upper Body | Offseason Surgery | 3 | 10/20 |
| Total Man Games Lost | 88 |