Wild goaltender Devan Dubnyk made 29 saves. He is 5-0-0 with seven goals allowed in his past five games.
WATCH: All Wild vs. Panthers highlights
Minnesota (16-8-4) is 10-3-0 at home.
"We need to keep climbing," Dubnyk said. "It's exciting to be in this spot with games at hand as well, and again, those games don't matter unless we win them, but it's still a good situation to be in.
"Winning is fun, so you just gotta keep doing it."
Dylan McIlrath scored, and Roberto Luongo made 12 saves on 17 shots before he was pulled in the third period. The goal was McIlrath's first with the Panthers.
"We knew coming in they were a disciplined, structured team," McIlrath said. "They made it tough on us all night. I don't think we did enough to create. Their goalie was seeing a lot of shots and we didn't get to the net."
Jason Zucker scored on a breakaway at 8:26 of the third period for a 5-0 lead. Mikko Koivu made it 4-0 at 6:04.
Erik Haula scored on a rebound at 4:11 of the second period for a 2-0 lead, and Eric Staal made it 3-0 at 9:46.
Zach Parise scored his first goal since Nov. 25 to make it 1-0 at 11:19 of the first period.
"I tried to shoot the puck a little more and get to the net a little more lately," Parise said. "I've had better chances. They haven't gone in. Fortunately, that one went in for me."
A goal by Florida forward Kyle Rau at 8:39 of the second period was overturned after a coach's challenge. The review determined the play was offside.
James Reimer replaced Luongo at 8:26 of the third period and made five saves. McIlrath scored at 15:36.
Panthers forward Jaromir Jagr did not have a point and remains four behind Mark Messier for second in NHL history (1,187-1,183). Wayne Gretzky is first with 2,857.
"It's a bad loss," Panthers coach Tom Rowe said. "We didn't generate enough scoring chances. We outshot them [30-22], I get it, but our shots were from the outside and we didn't have enough guys going to the net.
"When you're going through the rut that we're going through right now offensively, everybody presses a little more and they don't do what comes naturally."