The Penguins were 16-1-0 in their previous 17 home games against the Panthers.
"I don't think we had the juice that we have had in a number of the games, in most of the games this year," Penguins coach Mike Sullivan said. "But I think one of the challenges of this league is the grind of the schedule and good teams just have to understand how to manage those games. I thought we could have done a better job in certain circumstances in not putting ourselves in difficult positions where we had to defend when we were tired, or things of that nature."
Vatrano put Florida ahead 1-0 at 2:28 of the first period when he held off Penguins defenseman Kris Letang before shooting one-handed off Jarry, collecting the rebound and scoring on a wrist shot.
Jared McCann took a backhand pass from Dominik Simon for a snap shot from the slot, making it 1-1 at 3:52.
"I feel like we had some good opportunities tonight, but we have to be better defensively," McCann said. "That's what cost us."
Brett Connolly gave the Panthers a 2-1 lead with a wrist shot glove-side through traffic at 10:44.
Jarry kept it 2-1 after Aaron Ekblad received the puck in the left face-off circle with the goalie at the right post. Jarry pushed to his right, making it over in time to stop Ekblad's shot with the shaft of his stick 4:11 into the second period.
"It's just something where I was trying to watch what was behind me and try to put everything I could over there when the puck was thrown over there," Jarry said.
Hoffman made it 3-1 on a snap shot from the high slot at 8:52 of the third period, and Evgenii Dadonov extended the lead to 4-1, scoring into an empty net at 17:32.
Driedger won for the fourth time in five starts this season after making 11 saves in relief of Sergei Bobrovsky on Saturday. Bobrovsky allowed three goals on seven shots before being pulled in a 3-2 loss to the Buffalo Sabres.
"It was great, honestly. I was happy with the way we were able to shut it down in the third period," Driedger said. "Playing with a lead like that, good teams find ways to win. I thought we did everything that we needed to do in the third just to shut it down. Had a couple goals there, obviously, and played well defensively."
