Chiarot scored his first of the season on a wrist shot from the left point that deflected off the left skate of Blues defenseman Justin Faulk to tie it 1-1 at 12:01.
DeBrincat gave Detroit a 2-1 lead with a power-play goal at 19:24 when he tipped Moritz Seider’s long-range wrist shot past Binnington.
DeBrincat has scored in consecutive games after not getting a goal in his first eight games this season.
“Sometimes they go in, sometimes they don’t,” DeBrincat said. “Just got to keep going, keep shooting. I’m lucky enough to get the one today.”
Larkin made it 3-1 at 11:14 of the second period, chipping in a sharp seam pass in the slot that Simon Edvinsson sent from the left point.
Soderblom increased the lead to 4-1 at 12:56. Michael Rasmussen threw a pass from behind the net in front to Soderblom, who buried it with a quick snap shot.
Kyrou cut the deficit to 4-2 at 15:36 of the third period with a wrist shot from the slot. The goal extended his point streak to eight games (four goals, four assists).