Atkinson made it 4-2 with a power-play goal at 10:50 of the second period, and Milano made it 4-3 at 9:22 of the third when a shot by Zach Werenski was saved. Milano followed the shot and the puck went through the crease to him for his 15th.
"I tried to poke it in the net but he stole my goal," Werenski said.
Bertuzzi redirected Zetterberg's low-angle shot for a 1-0 lead at 3:50 of the first period. Atkinson scored at 6:16 to make it 1-1 during a 5-on-3 power play. Helm gave Detroit a 2-1 lead at 11:12, and Bertuzzi scored a power-play goal at 18:37 to make it 3-1.
Zetterberg's blind, backhand pass set up Nyquist's goal from the slot at 31 seconds of the second period, on the Red Wings' second power play, for a 4-1 lead.