Shea Theodore, Tomas Hertl and Braeden Bowman scored, and Jack Eichel had two assists for the Golden Knights. Carter Hart made 16 saves.
Vegas opened the season with a 5-2 win against the Chicago Blackhawks on Tuesday.
“You give yourself credit for fighting back, but you never want to put yourself in those situations,” Golden Knights captain Mark Stone said. “You’re never going to see this team quit. That’s why we’ve had some playoff success, regular-season success, as a team. We don’t quit. We continue to push. But when you get down in a hole 4-0, you’re not going to come back very often.”
Sennecke gave the Ducks 1-0 lead at 19:52 of the first period. Shortly after a Golden Knights power play ended, Carlsson sent a lead pass to Sennecke, who got behind the defense and lifted a shot past Hart on a breakaway.
“I was so tired,” Carlsson said. “I really didn’t think much. So I’m all alone, I tried to pass it as hard as I could in the air, and ended up being perfect.”
Killorn redirected a Noah Warren point shot at the edge of the right face-off circle at 1:33 of the second period to push the lead to 2-0.
It was the first career point for Warren, who was making his NHL debut.
“He was great,” Ducks coach Joel Quenneville said of Warren. “He looked good in the offensive point. Getting that shot through was a nice tip by ‘Killer,’ and I thought a lot of good things as far as his reach and his killing plays.”
Malott extended it to 3-0 just 55 seconds later at 2:28. Tim Washe deflected Jackson LaCombe's shot from the left point, and the puck then deflected off Malott's right skate from the low slot through the five-hole.
Carlsson pushed the lead to 4-0 at 7:03. Hart made the initial save on a A.J. Greer shot, but he was then caught out of position, allowing Carlsson to put the rebound into an open net.