Hamilton broke his left fibula in a collision with Columbus Blue Jackets forward Kevin Stenlund with 17 seconds left in the second period during a 3-2 loss at Nationwide Arena on Thursday. There is no timetable for the return of Hamilton, tied for third on the Hurricanes in scoring with 40 points (14 goals, 26 assists) and is fourth among NHL defensemen. He was selected to play in the 2020 Honda NHL All-Star Game but will be replaced by teammate Jaccob Slavin.
Carolina, looking to avoid its third straight loss following a three-game winning streak, is 5-7-0 in its past 12 games.
The Ducks, who ended a four-game losing streak with a 4-2 win at the Nashville Predators on Thursday, are 4-9-1 in their past 14 games.
Anaheim defeated Carolina 4-2 at Honda Center on Oct. 18.