With the loss, Anaheim dropped to 7-19-3 on the season and 2-12-3 on the road. The Ducks will continue their four-game Canadian road trip tomorrow in Toronto.
Rookie goaltender Lukas Dostal stopped 35-of-38 Ottawa shots in his fourth career NHL start and his first of the 2022-23 season.
Talbot registered his first shutout as a Senator with 32 saves. The veteran netminder now owns a 16-7-2 mark all-time against the Ducks, including wins in both matchups this season.
DeBrincat and Parker Kelly scored for the Senators, who now have points in three straight games (2-0-1) and improved to 12-14-2 (26 points) on the season. Longtime Flyers captain Claude Giroux tallied two assists.
The Sens claimed an early two-goal lead with a strong first period on home ice, outshooting the Ducks 11-5.
Kelly opened the scoring on a impressive deflection, lifting a low point shot by defenseman Nikita Zaitsev up over Dostal's left shoulder.
The goal was Kelly's first of the season and ninth of his 68-game NHL career.
Anaheim fell to 4-12-3 on the season when surrendering the game's first goal.
DeBrincat doubled the lead five minutes later as the finisher on a perfectly executed power-play faceoff set play. Brady Tkachuk won the draw cleanly back to Thomas Chabot at the point, who quickly slid the puck along the blueline to Giroux on the far side of the ice. Giroux worked his way downhill, looking for a centering pass through the Anaheim defense before finding a lane and giving Dostal little chance with a perfect feed to DeBrincat alone on the backdoor.
Ottawa scored five power-play goals in two games against Anaheim this season.
Senators forwards Tim Stutzle and Tyler Motte both left the game with injuries in the first period and did not return.
Dostal helped keep the deficit at just two early in the second period with consecutive left pad robberies of Pinto in tight, holding his ground when the rebound kicked right back to the Ottawa centerman.