The Golden Knights have outscored opponents 17-7 during their five-game winning streak, including a 3-0 victory against the Canucks on March 3.
Vegas is in third place in the Pacific Division, nine points behind the second-place San Jose Sharks and eight points ahead of the fourth-place Arizona Coyotes.
The Canucks, 2-5-2 in their past nine games and 4-9-3 in their past 15, have scored two goals or fewer in nine of their past 12 games, including three shutouts.
Vancouver is nine points behind the Minnesota Wild for the second wild card into the Stanley Cup Playoffs from the Western Conference.