Guillaume Brisebois is the younger brother of Mathieu Brisebois, a defenseman for Nottingham in the Elite Ice Hockey League. He was selected by Acadie-Bathurst with the No. 5 pick in the 2013 Quebec Major Junior Hockey League Draft.
After three seasons, Brisebois was traded to Charlottetown during the 2016 QMJHL draft and was voted captain by his teammates two months later. He was chosen by the Vancouver Canucks in the third round (No. 66) of the 2015 NHL Draft and the defenseman signed a three-year, entry-level contract Dec. 10.