Binnington, who will make his fifth straight start, is 6-1-1 with a 1.63 goals-against average and .933 save percentage in eight starts this season and has allowed two goals or fewer in seven of them.
The Blues, seeking their third win in a row, are 6-2-1 in their past nine games.
Goalie James Reimer will make his second consecutive start for the Panthers, who are 4-1-0 in their past five games following a seven-game losing streak (0-5-2). Reimer is 5-1-2 with a 2.29 GAA and .924 save percentage in his past nine games (seven starts).