Ducks captain Ryan Getzlaf said they need to do a better job controlling the puck.
"The compete level has to go up through the roof," Getzlaf said. "When you're in a situation against a team like that, it's about being hard on pucks, making strong plays, especially early in hockey games."
The Ducks allowed the first eight shots on goal before outshooting the Blues 9-3 the rest of the first period.
Jones pushed in a rebound following a St. Louis turnover in its own zone to make it 3-1 at 16:59. It was his first goal.
Perron made it 4-1 at 7:30 of the second period when he scored off a centering pass from Ryan O'Reilly.
Kyle Clifford scored on a delayed penalty at 2:59 of the third period to make it 5-1, and Vince Dunn made it 6-1 with a power-play goal at 5:17.
The Blues and Ducks are scheduled to play here again Sunday.
"One nice thing about having a back-to-back is you get to get back at it," Getzlaf said. "When you come out and lay an egg, so to speak, like we did tonight, you get to forget about it in a half an hour here and get ready for the next one, go out and prove ourselves."
NOTES: The Washington Capitals hold the NHL record for the three fastest goals to start a game (1:21 on Dec. 19, 1986; a 6-4 loss at the New Jersey Devils). ... The Blues' three opening goals were the fastest in an NHL game since the Detroit Red Wings' on Dec. 4, 1987 (1:48; a 12-0 win against the Chicago Blackhawks). … Ducks forward Derek Grant missed the game with an upper-body injury and is day to day. Isac Lundestrom was recalled from San Diego of the American Hockey League to take Grant's place and had two shots on goal in 15:20. ... Anaheim forward David Backes made his season debut and had three blocked shots and three hits in 14:32. He played his first 10 NHL seasons with the Blues and is seventh in their history in games (727), goals (206) and points (460).