The Wild scored twice in 45 seconds in the first to take a 2-0 lead. Staal scored on a redirect at 4:42 to make it 1-0, and Seeler scored on a slap shot through traffic at 5:27 to make it 2-0.
"It's nice to have that first one go in," Seeler said. "It was exciting and I've just tried to get more pucks to the net and create more offense. We played so well as a team tonight. It was a great team win. It was fun."
O'Reilly scored on the power play, the 10th time in 12 games, and fifth straight, the Blues have scored with the man advantage this season, to make it 2-1 at 11:32, but JT Brown's first goal with the Wild made it 3-1 at 18:09 after Blues defenseman Jay Bouwmeester turned the puck over and Brown scored on a breakaway.
"The way I saw that play, yes, his job is to skate there," Blues coach Mike Yeo said of Bouwmeester. "I think maybe he has an option, I think his support wasn't that great. I'm not going to pin it on one guy there."
Matt Dumba brought the lead to 4-1 at 15:32 of the second period on a shot from the slot in which the Blues challenged for offside, and Fehr made it 5-1 at 9:15 of the third on a rebound.