Alex DeBrincat scored twice and Lucas Raymond also had a goal for Detroit (40-27-8), which won for the second time in six games (2-4-0). John Gibson, who was pulled from his previous two starts, made 32 saves.
Tyson Foerster and Travis Konecny scored for Philadelphia (37-26-12). Samuel Ersson made 15 saves.
DeBrincat put the Red Wings ahead 1-0 with a power-play goal at 18:49 of the first period. Kane found DeBrincat alone in the middle of the zone above the face-off circles, and he scored past Ersson's glove.
Foerster, playing for the first time since Dec. 1, tied the game 1-1 31 seconds into the second period. A loose puck rolled to Foerster in the high slot, he dragged it back and shot it past Gibson's blocker. The forward had missed the previous 49 games because of an arm injury.
Raymond scored to make it 2-1 at 18:29. J.T. Compher one-touched Simon Edvinsson's centering pass out of the right corner to Raymond on the left side, and he scored from along the goal line on the left side.
Kane made it 3-1 at 9:37 of the third period when he finished a 2-on-1 rush with a shot that beat Ersson to the short side, over his right shoulder.
The Flyers made it 3-2 at 10:29 when Porter Martone's shot deflected off Konecny as he drove to the net. The goal initially was disallowed for goaltender interference, but the call was overturned after a coach's challenge. The assist was Martone’s first NHL point in his second game.
DeBrincat made it 4-2 at 10:44 when his shot from along the goal line on the left side of the Philadelphia zone deflected off the stick of Flyers defenseman Rasmus Ristolainen and past Ersson.
