Carter Mazur scored his first NHL goal, and Alex DeBrincat and Emmitt Finnie also scored for the Red Wings (7-5-3), who have won three of their past four. Andrew Copp and Moritz Seider each had two assists. Daniil Tarasov, who played for Florida last season, made 23 saves.
Sam Reinhart, Aaron Ekblad and Sam Bennett scored for the Panthers (8-5-2), who had won their past three games.
Jacob Markstrom made 24 saves in his first start since Oct. 17. He sustained an upper-body injury in practice two days later and missed the past five games.
Mazur gave the Red Wings a 1-0 lead at 5:26 of the first period. Seider threw the puck along the boards from the right point and it landed on Mazur's stick. Mazur skated into the left face-off circle and put a wrist shot over Markstrom's left shoulder.
Florida tied it 1-1 at 14:19 after Sandis Vilmanis got a piece of a clearing shot from Tarasov deep in the Detroit zone. Verhaeghe made a drop pass to Reinhart, who buried a quick wrist shot from the edge of the right circle to extend his goal streak to three games.
At 1:26 into the second period, Detroit took a 2-1 lead when DeBrincat finished a cross-ice feed from Viktor Arvidsson on a 3-on-1 rush.
The Panthers evened the score 2-2 while short-handed at 15:25. Ekblad jumped on a loose puck below the goal line and backhanded it in off Tarasov's left skate.
Faulk gave Detroit the lead back 3-2 early in the third period, scoring on the power play at 2:08 by one-timing a pass from Copp.
Just 45 seconds later, Brandsegg-Nygard made it 4-2 by charging the net and scoring off a shovel pass from Lucas Raymond at 2:53.
With Markstrom on the bench for the extra attacker, the Panthers pulled within 4-3 at 16:40 when Matthew Tkachuk sent a pass across the goal line to a Bennett who redirected it five-hole as he crashed the net.
With 2:06 remaining in the game, the Florida pulled Markstrom again, but failed to get the equalizer.
Finnie scored an empty-net goal at 17:57 for the 5-3 final.
