Axel Sandin-Pellikka and Dylan Larkin also scored for the Red Wings (17-11-3), who have won three in a row and are 4-0-2 in their past six games. Patrick Kane and Andrew Copp had two assists each, and John Gibson made 34 saves.
Kane is 11 points from breaking Mike Modano’s NHL record for points by a player born in the United States, with 1,364 points (497 goals, 867 assists) in 1,324 games for the Chicago Blackhawks, New York Rangers and Red Wings.
The forward is three goals away from joining Modano (561), Keith Tkachuk (538), Jeremy Roenick (513) and Joe Mullen (502) as the fifth U.S.-born player in NHL history to score 500 goals.
Joel Farabee, Matt Coronato and MacKenzie Weegar scored for the Flames (12-16-4), who trailed 4-0 heading into the third period. Nazem Kadri had two assists, and Devin Cooley made 23 saves.
Farabee started the Flames comeback when he scored on a penalty shot at 8:02 to make it 4-1 after being held from behind by Sandin-Pellikka while the Flames were killing a penalty. Farabee beat Gibson with a shot under his glove for his first NHL penalty-shot goal.
Coronato scored 65 seconds later at 9:07 to make it 4-2 when he one-timed a pass from Kadri over Gibson’s glove.
Weegar cut Detroit’s lead to 4-3 at 14:40 when his point shot through traffic beat Gibson.
DeBrincat gave the Red Wings a 1-0 lead at 1:02 of the first period when he one-timed a pass from Kane past Cooley.
Sandin-Pellika extended Detroit’s lead to 2-0 at 4:33 by one-timing a pass from DeBrincat past Cooley.
DeBrincat made it 3-0 at 7:41 of the second period with a wrist shot from the slot after taking a pass from Copp, who forced a turnover by Calgary forward Adam Klapka along the boards.
Larkin increased Detroit’s lead to 4-0 at 9:09 when he outraced Flames forward Blake Coleman into the Calgary zone before lifting a shot over Cooley’s blocker.
