Scheifele kept the puck on a 2-on-1 and shot short side by Anton Khudobin for the win.
"It's always big," said Scheifele, whose ninth career NHL overtime goal tied him with Ilya Kovalchuk for the most in Winnipeg/Atlanta Thrashers history. "The intensity always ramps up a little bit for Central Division matchups. We did a good job tonight of just sticking with it. Awesome to get the two points in overtime."
WATCH: [All Stars vs. Jets highlights]
Patrik Laine and Andrew Copp scored, and Connor Hellebuyck made 26 saves for the Jets (10-7-1), who are 4-0-1 in their past five games and 5-1-1 in their past seven.
"It's definitely a bigger game," Copp said. "We've got a couple rivals in there, just with teams we've played playoff series with, and teams that we see so often. It's going to be tight again this year. It's tight every year, so we know how important these games are. We're going to see a lot of these teams coming up in the next month, two months, so we've got to make sure that we're winning these games and getting ahead of these teams as much as we can."